Hemophagocytic lymphohistiocytosis- familial- 2

Overview

Hemophagocytic lymphohistiocytosis, familial, 2: A rare recessively inherited disorder involving an overactive immune system. More specifically, the body becomes infiltrated by large numbers of histiocytes (macrophages) that accumulate in various organs such as the liver, spleen, bone marrow, skin and central nervous system. It usually only occurs in infants and young children. Type 2 is caused by a defect on chromosome 10q22.

Symptoms

The list of signs and symptoms mentioned in various sources for Hemophagocytic lymphohistiocytosis, familial, 2 includes the 27 symptoms listed below: * Enlarged liver * Enlarged spleen * Lymphadenopathy * Pancytopenia * Fever * Rash * Recurring infection * Low blood fibrinogen level * High blood triglyceride level * Hemophagocytosis * Bleeding gums * Low blood count * Swollen gums * Tooth loss * Abdominal pain * Weight loss * Vomiting * Diarrhea * Jaundice * Pale skin * Easy bruising * Malaise * Failure to thrive * Anemia * Neutropenia * Thrombocytopenia * High ferritin level

Causes

* Abdominal pain * Anemia * Bleeding gums * Diarrhea * Easy bruising * Enlarged liver * Enlarged spleen * Failure to thrive * Fever * Jaundice * Lymphadenopathy * Malaise * Pale skin * Rash * Recurring infection * Swollen gums * Thrombocytopenia * Tooth loss * Vomiting * Weight loss

Diagnosis

The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Hemophagocytic lymphohistiocytosis, familial, 2. This medical information about signs and symptoms for Hemophagocytic lymphohistiocytosis, familial, 2 has been gathered from various sources, may not be fully accurate, and may not be the full list of Hemophagocytic lymphohistiocytosis, familial, 2 signs or Hemophagocytic lymphohistiocytosis, familial, 2 symptoms. Furthermore, signs and symptoms of Hemophagocytic lymphohistiocytosis, familial, 2 may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Hemophagocytic lymphohistiocytosis, familial, 2 symptoms.