University of Miami – x Linked Combined Immunodeficiency

Access Program Information

This protocol is designed to enable access to related or unrelated CD34 cells manufactured
using the CliniMACS (Miltenyi) under the HUD designation for patients needing T cell
depleted allogeneic grafts for hematopoietic stem cell transplant (HSCT). This will include
patients with inherited immunodeficiency disorders as well as patients with malignancies,
bone marrow failure, and other rare diseases amenable to HSCT. Finally, patients with poor
graft function and Graft Versus Host Disease(GVHD) after a previous HSCT may require a boost
of T-cell depleted donor Peripheral Blood Stem Cell (PBSCs) or bone marrow cells that are
CD34 selected using the CliniMACS device ENROLLMENT BY INVITATION ONLY