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Brain Tissue Collection for Neuropathological Studies

Descriptive Information
Brief Title † Brain Tissue Collection for Neuropathological Studies
Official Title † Brain Procurement for the Human Brain Collection Core
Brief Summary The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders. This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders. We do not accept prospective donations.
Detailed Description The knowledge of how affected tissue deviates from normal control tissue is an integral part of fully understanding a neurological or psychiatric disorder. The purpose of this protocol is to establish a coordinating program with the Office of the Chief Medical Examiner in Washington, DC, the Virginia Office of the Chief Medical Examiner, Central District, and Virginia the Office of the Chief Medical Examiner, Northern District for the donation of brain tissue. Dissected brain tissue from selected brain regions, including but not limited to the dorsolateral prefrontal cortex and hippocampal formation, will be assembled from large cohorts of normal controls and schizophrenic subjects. The expression of mRNA and protein for selected molecules, chosen on the basis of their genetic association with schizophrenia, will be measured with a variety of assays including but not limited to qPCR and Western blots. Outcome measures are the statistical comparison within normal controls of mRNA and/or protein levels in groups segmented by genotype. Similar comparisons will be made between schizophrenic cohorts and normal controls, in a diagnosis by genotype analysis with an ANOVA, or when appropriate an ANCOVA (controlling for variables such as age, race, gender, and postmortem interval).
Study Phase N/A
Study Type † Observational
Study Design †
Primary Outcome Measure †
Secondary Outcome Measure †
Condition † Bipolar Disorder Depression Anxiety Disorders Schizophrenia Tourette's Syndrome Brain Diseases
Intervention †
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 2500
Start Date † May 29, 1990
Completion Date
Primary Completion Date
Eligibility Criteria † - INCLUSION CRITERIA: Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls. EXCLUSION CRITERIA: No living subjects are enrolled in this protocol. Tissue is obtained after death, with the permission of next of kin, or from existing institutions with appropriate samples via an MTA or other applicable agreement. Brain tissue is excluded from collection if there is a previously known history of strokes, lesions, or other major neuropathological abnormalities prior to the consenting process.
Gender All
Ages N/A - N/A
Accepts Healthy Volunteers Accepts Healthy Volunteers
Contacts †† Barbara Lipska, M.D., (301) 496-9501, lipskab@intra.nimh.nih.gov
Location Countries † United States
Administrative Information
NCT ID † NCT00001260
Organization ID 900142
Secondary IDs †† 90-M-0142
Responsible Party Sponsor
Study Sponsor † National Institute of Mental Health (NIMH)
Collaborators ††
Investigators † Principal Investigator: Jose A Apud, M.D., National Institute of Mental Health (NIMH)
Information Provided By
Verification Date February 1, 2017
First Received Date † November 3, 1999
Last Updated Date April 20, 2017
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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