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Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome

Descriptive Information
Brief Title † Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome
Official Title †
Brief Summary OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushing's syndrome. II. Determine whether reduced hippocampal volume is associated with specific memory dysfunction. III. Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction. IV. Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized.
Detailed Description PROTOCOL OUTLINE: Patients undergo a psychiatric evaluation for mood and cognition during confirmation of diagnosis. Neuropsychologic exams include pencil and paper test and a cognitive assessment. Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests. The hippocampal complex volume is assessed with coronal magnetic resonance imaging. There is a follow-up 1 year after the initiation of treatment.
Study Phase N/A
Study Type † Observational
Study Design † Primary Purpose: Screening
Primary Outcome Measure †
Secondary Outcome Measure †
Condition † Cushing's Syndrome
Intervention †
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 12
Start Date † August 1994
Completion Date
Primary Completion Date
Eligibility Criteria † PROTOCOL ENTRY CRITERIA: - Adults and teenagers with untreated, spontaneous active Cushing's syndrome - Diagnosis verified at the University of Michigan Medical Center, including the following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol secretion rate, and plasma cortisol level - Lack of normal circadian cortisol secretion and failure to suppress following 2 mg of dexamethasone
Gender Both
Ages 15 Years - 80 Years
Accepts Healthy Volunteers No
Contacts ††
Location Countries † United States
Administrative Information
NCT ID † NCT00004326
Organization ID 199/11872
Secondary IDs †† UMMC-1043
Responsible Party
Study Sponsor † National Center for Research Resources (NCRR)
Collaborators †† University of Michigan
Investigators † Study Chair: Monica N. Starkman, University of Michigan
Information Provided By
Verification Date April 2002
First Received Date † October 18, 1999
Last Updated Date June 23, 2005
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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