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Nutritional Aspects of Rett Syndrome

Descriptive Information
Brief Title † Nutritional Aspects of Rett Syndrome
Official Title †
Brief Summary OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in healthy controls. II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining, sitting, and standing, by whole-room indirect calorimetry and isotope dilution. III. Quantify activity patterns by time-motion studies using 24-hour activity records and 12-hour videotaping. IV. Correlate 24-hour activity patterns with 24-hour heart rate telemetry and short-term oxygen consumption. V. Estimate 24-hour fecal and urinary energy losses. VI. Determine body composition by clinical anthropometry, whole-body potassium counting, and total-body electrical conductance. VII. Calculate apparent energy needs based on measurement of energy intake and expenditure.
Detailed Description PROTOCOL OUTLINE: All participants undergo extensive nutritional and metabolic assessment with body composition evaluation. Studies include macronutrient intake, body fat, lean muscle mass, metabolic rate, and time-action studies; and 24-hour cardiac telemetry. Rett syndrome girls also receive a hemogram and hand x-ray.
Study Phase N/A
Study Type † Interventional
Study Design † Primary Purpose: Diagnostic
Primary Outcome Measure †
Secondary Outcome Measure †
Condition † Rett Syndrome
Intervention † ProcedureMetabolic assessment with body composition evaluation
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status † Procedure
Estimated Enrollment †
Start Date † May 1993
Completion Date
Primary Completion Date
Eligibility Criteria † PROTOCOL ENTRY CRITERIA: Patients aged 5 to 18 with Rett syndrome Able to sleep and awaken alone
Gender Female
Ages 5 Years - 18 Years
Accepts Healthy Volunteers Accepts Healthy Volunteers
Contacts ††
Location Countries †
Administrative Information
NCT ID † NCT00004656
Organization ID 199/11814
Secondary IDs †† BCM-CNRC-H1637
Responsible Party
Study Sponsor † Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborators †† Baylor College of Medicine
Investigators † Study Chair: Kathleen J. Motil, Baylor College of Medicine
Information Provided By
Verification Date February 1999
First Received Date † February 24, 2000
Last Updated Date June 23, 2005
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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