Aortic Distensibility

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Disease Information

Descriptive Information
Brief Title † Aortic Distensibility
Official Title † ECG-Gated Multidetector CT of Aortic Distensibility FAMRI
Brief Summary Can software be developed to automatically aid in the measurement of abdominal aortic aneurysms, and is there a way to predict future rupture or growth of abdominal aortic aneurysms.
Detailed Description Hypothesis: ECG-gated multidetector CT and ECG-gated Dual Source CT can be used to create multiple volumetric datasets of the abdominal aorta over the time period of the cardiac cycle, allowing for direct and regional calculations of abdominal aortic distensibility over the entire volume of the abdominal aorta, providing insight into risk of abdominal aortic aneurysm rupture and early large vessel stiffness.
Study Phase N/A
Study Type † Observational
Study Design † Observational Model: Cohort, Time Perspective: Prospective
Primary Outcome Measure † In year one, this data will be used to develop pulsatility software and test robustness.
Secondary Outcome Measure † In year two, the time-resolved CT angiographic datasets from each patient will be analyzed to determine peak AAA pulsatility and peak AAA relative pulsatility (to cross-sectional area within the aneurysm).
Condition † Abdominal Aortic Aneurysm
Intervention †
Study Arms / Comparison Groups 1 Aortic aneurysm repair 2 Aortic aneurysm growth 3 Aortic aneurysm growth stable.
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 67
Start Date † November 2004
Completion Date July 2009
Primary Completion Date July 2009
Eligibility Criteria † Inclusion Criteria: - AAA must be at least 3 cm to a maximum 4.9cm cross-sectional diameter. - BMI 31 or less. - Creatinine results 2.0. - Creatinine 1.4 for those who are scheduled for US. - Atrial fibrillation or other arrythmia. - Known AAA greater than 5 cm in size. - Allergy to contrast dye.
Gender Both
Ages 18 Years - N/A
Accepts Healthy Volunteers No
Contacts ††
Location Countries † United States
Administrative Information
NCT ID † NCT00587977
Organization ID 1994-04
Secondary IDs †† 2A3360, FAMRI 2
Responsible Party
Study Sponsor † Mayo Clinic
Collaborators †† Flight Attendant Medical Research Institute
Investigators † Principal Investigator: Joel G. Fletcher, M.D., Mayo Clinic Rochester Minnesota
Information Provided By
Verification Date November 2012
First Received Date † December 22, 2007
Last Updated Date November 7, 2012
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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