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Biomarkers of Aneurysm Wall Strength

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Disease Information

Descriptive Information
Brief Title † Biomarkers of Aneurysm Wall Strength
Official Title † Biological and Biochemical Markers of Aneurysm Wall Degradation; Towards Non-Invasive Wall Strength Analysis.
Brief Summary The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
Detailed Description Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
Study Phase N/A
Study Type † Observational
Study Design † Observational Model: Case Control, Time Perspective: Prospective
Primary Outcome Measure † Aneurysm wall strength
Secondary Outcome Measure † Extra Cellular Matrix components (Glucoaminoglycans)
Condition † Abdominal Aortic Aneurysm
Intervention †
Study Arms / Comparison Groups 1 Patients scheduled for elective conventional aneurysm repair 2 Patients scheduled for emergent conventional aneurysm repair 3 Patients scheduled for aortic bypass surgery
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 50
Start Date † June 2007
Completion Date January 2010
Primary Completion Date January 2010
Eligibility Criteria † Inclusion Criteria: - Patient scheduled for transabdominal aortic surgery Exclusion Criteria: - Patient characteristics and aneurysm anatomy suitable for endovascular repair - Previous aortic surgery
Gender Both
Ages 18 Years - N/A
Accepts Healthy Volunteers No
Contacts †† Maarten Truijers, MD, 0031-24-3615333, M.Truijers@chir.umcn.nl
Location Countries † Netherlands
Administrative Information
NCT ID † NCT00740740
Organization ID Wallstrength_01
Secondary IDs ††
Responsible Party
Study Sponsor † Radboud University
Collaborators ††
Investigators † Principal Investigator: Jan Blankensteijn, Radboud University
Information Provided By
Verification Date August 2008
First Received Date † August 22, 2008
Last Updated Date August 22, 2008
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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