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Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination

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Disease Information

Descriptive Information
Brief Title † Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination
Official Title † Immune Response After Booster Vaccination in HIV - Infected Patients Who Ever Received Rabies Primary Vaccination
Brief Summary Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.
Detailed Description The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.
Study Phase N/A
Study Type † Interventional
Study Design † Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Primary Outcome Measure † Rabies Neutralizing Antibody Titers
Secondary Outcome Measure †
Condition † HIV Rabies
Intervention † Biologicalrabies vaccines on day 0 and 3
Study Arms / Comparison Groups Rabies vaccines on day 0 and 3 Cell culture Rabies vaccines on day 0 and 3
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status † Biological
Estimated Enrollment † 33
Start Date † February 2011
Completion Date December 2013
Primary Completion Date December 2013
Eligibility Criteria † Inclusion Criteria: - HIV infected patients 18-60 years of age - Ever received primary rabies immunization Exclusion Criteria: - currently have any active opportunistic infections - have received blood or blood product within previous 3 months - history of allergy to vaccine or any vaccine components - currently received anti-malarial drugs
Gender Both
Ages 18 Years - 60 Years
Accepts Healthy Volunteers Accepts Healthy Volunteers
Contacts ††
Location Countries † Thailand
Administrative Information
NCT ID † NCT01286493
Organization ID RC5303
Secondary IDs ††
Responsible Party Principal Investigator
Study Sponsor † Queen Saovabha Memorial Institute
Collaborators ††
Investigators † Principal Investigator: Suda Sibunruang, MD, Queen Saovabha Memorial Institute
Information Provided By
Verification Date May 2014
First Received Date † January 26, 2011
Last Updated Date May 18, 2014
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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