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Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A

Descriptive Information
Brief Title † Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A
Official Title † Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A
Brief Summary This exploratory cross-sectional study proposes, firstly, to objectify in a population of Charcot-Marie-Tooth disease type 1A (CMT 1A)if there is a correlation between the recording of electrical parameters and upper limb muscle strength of the thigh and in a second step, to seek a relationship between the measured parameters.
Detailed Description Patients suffering from CMT 1A neuropathy will be invited to go through a series of tests such as: - Electromyography - Isokinetic test - Podiatric assessment - Functional evaluations: Hand dexterity, limbs muscles strength - Quality of life assessment with questionnaires
Study Phase N/A
Study Type † Observational
Study Design † Time Perspective: Cross-Sectional
Primary Outcome Measure † axonal loss
Secondary Outcome Measure † Muscle strength
Condition † Charcot-Marie-Tooth Type 1A Neuropathy
Intervention †
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 60
Start Date † December 2012
Completion Date December 2013
Primary Completion Date October 2013
Eligibility Criteria † Inclusion Criteria: - Patients older than 18 years - Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2) - Listening and written French - Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome. - Strength of the quadriceps superior to 2/5 MMT MRC Exclusion Criteria: - Presence of other neurological comorbidity - Presence of coronary artery disease unstabilized - Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy. - Gait trouble of other origin - Patients unable to give their consent. - Intellectual deficit that does not allow to comply with tests
Gender Both
Ages 18 Years - N/A
Accepts Healthy Volunteers No
Contacts †† Patrick LACARIN, 04 73 75 11 95, placarin@chu-clermontferrand.fr
Location Countries † France
Administrative Information
NCT ID † NCT01750710
Organization ID CHU-0128
Secondary IDs ††
Responsible Party Sponsor
Study Sponsor † University Hospital, Clermont-Ferrand
Collaborators ††
Investigators † Principal Investigator: Emmanuel COUDEYRE, University Hospital, Clermont-Ferrand
Information Provided By
Verification Date December 2012
First Received Date † November 16, 2012
Last Updated Date December 13, 2012
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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