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Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

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Disease Information

Descriptive Information
Brief Title † Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)
Official Title † Etude Comparative en Imagerie Par résonnance magnétique et Par Enregistrement électroencéphalographique du Couplage Neurovasculaire Dans l'Angiopathie Cadasil
Brief Summary The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.
Detailed Description Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).
Study Phase N/A
Study Type † Observational
Study Design † Observational Model: Case Control
Primary Outcome Measure † model-derived parameters of neurovascular coupling
Secondary Outcome Measure †
Condition † CADASIL
Intervention †
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status †
Estimated Enrollment † 60
Start Date † January 2015
Completion Date December 2015
Primary Completion Date December 2015
Eligibility Criteria † Inclusion Criteria: - CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance Exclusion Criteria: - MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent
Gender Both
Ages 18 Years - 60 Years
Accepts Healthy Volunteers Accepts Healthy Volunteers
Contacts ††
Location Countries † France
Administrative Information
NCT ID † NCT02071784
Organization ID C13-62
Secondary IDs †† 2014-A00200-47
Responsible Party Sponsor
Study Sponsor † Institut National de la Santé Et de la Recherche Médicale, France
Collaborators ††
Investigators † Principal Investigator: Hugues Chabriat, MD PhD, INSERM and APHP
Information Provided By
Verification Date March 2015
First Received Date † February 24, 2014
Last Updated Date March 23, 2015
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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