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Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis

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Disease Information

Descriptive Information
Brief Title † Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis
Official Title † OSCILLATION MECHANICS OF THE RESPIRATORY SYSTEM ASBESTOS EXPOSED : Early Diagnosis
Brief Summary Inhalation of dust containing asbestos results in a process of interstitial pulmonary fibrosis called asbestosis. The Forced Oscillation Technique (FOT) evaluates the respiratory mechanics describing resistive, elastic and inertial properties. We believe that this technique may contribute to the early diagnosis of asbestosis.
Detailed Description The aims of this study were (1) to use the FOT to analyze how respiratory mechanics is affected in patients with asbestos exposed, (2) to identify the best FOT parameters for the diagnosis of respiratory changes in these patients (3) Assess whether the presence of obstructive changes is associated with the smoking habit.The control group (CG) included 24 subjects with normal spirometric data and without a history of smoking or pulmonary disease formed by workers and students UERJ and FioCruz. Volunteers with asbestos exposure were from the Department of CESTEH/ FioCruz, totaling 24 exposed and 7 with diagnoses of asbestosis. The diagnosis of asbestosis was established based on a history of substantial exposure to asbestos dusts and compatible radiological features, together with exclusion of other competing diagnoses. The tests included a standardized questionnaire on respiratory symptoms, clinical evaluation; Plain radiography of the chest; FOT, plethysmography and spirometry, in that order.
Study Phase N/A
Study Type † Observational
Study Design † Time Perspective: Cross-Sectional
Primary Outcome Measure † changes in pulmonary mechanicals
Secondary Outcome Measure †
Condition † Asbestosis
Intervention † Otherevaluated lung function
Study Arms / Comparison Groups
Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status † Other
Estimated Enrollment † 2
Start Date † March 2013
Completion Date March 2016
Primary Completion Date March 2016
Eligibility Criteria † Inclusion Criteria: - diagnosis of asbestosis Exclusion Criteria: - other diseases
Gender Both
Ages N/A - N/A
Accepts Healthy Volunteers Accepts Healthy Volunteers
Contacts †† Paula Sá, research, 552123340705, paulamorisco@hotmail.com
Location Countries † Brazil
Administrative Information
NCT ID † NCT02280343
Organization ID UERJ
Secondary IDs ††
Responsible Party Principal Investigator
Study Sponsor † Rio de Janeiro State University
Collaborators ††
Investigators † Principal Investigator: Paula Sá, research, Universidade do Estado do Rio de Janeiro:Brazil
Information Provided By
Verification Date June 2015
First Received Date † October 24, 2014
Last Updated Date June 30, 2015
† Required WHO trial registration data element.
†† WHO trial registration data element that is required only if it exists.
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