Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma

Descriptive Information
Brief Title ^†	Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
Official Title ^†	Präklinische Studie Zur Etablierung Einer Immuntherapie für Das Nebennierenrindenkarzinom - Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
Brief Summary	Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy with poor prognosis. Surgical resection of the tumor is the treatment of choice. However, even after complete resection more than 80 % of patients will experience recurrence of disease. Therefore, new treatment options are urgently needed. This pre-clinical study try to lay the foundations for a successful immunotherapy in patients with ACC.
Detailed Description
Study Phase	Phase 0
Study Type ^†	Observational
Study Design ^†	Observational Model: Case Control, Time Perspective: Prospective
Primary Outcome Measure ^†	To find reasonable antigens for a vaccination therapy in ACC
Secondary Outcome Measure ^†
Condition ^†	Adrenocortical Carcinoma Cushing's Syndrome
Intervention ^†
Study Arms / Comparison Groups
Publications *
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status ^†
Estimated Enrollment ^†	70
Start Date ^†	September 2005
Completion Date	December 2011
Primary Completion Date	December 2010
Eligibility Criteria ^†	Inclusion Criteria: patients with histological proven adrenocortical carcinoma healthy persons as control group Life expectancy > 6 months Exclusion Criteria: autoimmune diseases severe clinical condition
Gender	Both
Ages	18 Years - N/A
Accepts Healthy Volunteers	Accepts Healthy Volunteers
Contacts ^††	, , , ,
Location Countries ^†	Germany,
Administrative Information
NCT ID ^†	NCT00457587
Organization ID	Wue-Immuno-ACC-83/05
Secondary IDs ^††
Responsible Party	,
Study Sponsor ^†	University of Wuerzburg
Collaborators ^††	Deutsche Krebshilfe e.V., Bonn (Germany)
Investigators ^†	Principal Investigator: Martin Fassnacht, MD, University of Wuerzburg
Information Provided By	University of Wuerzburg
Verification Date	July 2010
First Received Date ^†	April 4, 2007
Last Updated Date	July 7, 2010

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.