Atypical mycobacteriosis- familial

Synonyms

Atypical mycobacterial infection, disseminated
Atypical mycobacterial infection, familial disseminated
Mycobacterial disease, Mendelian susceptibility to
MSMD

Overview

A very rare group of disorders where a person without an immune deficiency is susceptible to infection by weak mycobacterial organisms, nontuberculous and environmental mycobacteria e.g. Calmette-Guerin Bacillus (BCG). The severity of the disorder is greatly variable and ranges from a localized recurring non-tuberculous mycobacterial infection to a potentially fatal BCG infection. Most people who are infected with these organisms have no symptoms but a genetic mutation in some people makes them more susceptible.

Symptoms

  • Salmonella infection
  • Mycobacterium avium sepsis
  • Lymphadenopathy
  • Infection following BCG immunization
  • Recurring tuberculosis
  • Recurring mycobacterial infection
  • Salmonella osteomyelitis

Resources

  • NIH