Nonkeratan-sulfate-excreting Morquio syndrome
Overview
Nonkeratan-sulfate-excreting Morquio syndrome: A rare inherited biochemical disorder characterized by the accumulation of mucopolysaccharides (glycosaminoglycans) in various body tissues due to insufficient amounts of certain enzymes needed to break it down. This disorder is distinguished form other similar conditions by the fact that no keratosulfate is excreted in the urine
Symptoms
The list of signs and symptoms mentioned in various sources for Nonkeratan-sulfate-excreting Morquio syndrome includes the 32 symptoms listed below: * Mild cloudy corneas * Skeletal anomalies * Severe mental retardation * Abnormally shaped sella turcica * Wide upper arm bone shaft * Short trunk * Corneal opacities * Flattened vertebrae * Impaired hearing * Kyphosis * Lordosis * Curved spine * Odontoid hypoplasia * Osteoporosis * Joint hypermobility * Coarse facial features * Projecting jaw * Broad mouth * Small teeth * Thin teeth enamel * Dwarfism * Hyperextension of neck * Long arms * Long legs * Spinal cord compression * Protruding abdomen * Dysostosis multiplex * Progressive spinal deformity * Short neck * Pectus carinatum * Knock-knee * Flat feet
Causes
* Coarse facial features * Corneal opacities * Curved spine * Dwarfism * Flat feet * Flattened vertebrae * Impaired hearing * Joint hypermobility * Knock-knee * Kyphosis * Long arms * Long legs * Lordosis * Osteoporosis * Pectus carinatum * Protruding abdomen * Short neck * Short trunk * Skeletal anomalies * Small teeth