osteosarcoma, limb anomalies, and erythroid macrocytosis

Overview

OSLAM syndrome (osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow syndrome) is characterised by the association of osteosarcoma, limb anomalies (clinodactyly with brachymesophalangy, bilateral radioulnar synostosis and absence of one digital ray of the foot) and red cell macrocytosis without anaemia. It has been described in three out of nine children from one family. Autosomal dominant inheritance was suggested.

Symptoms

* Bone cancer * Curved fifth fingers * Enlarged red blood cells * Dental decay * Short stature