Senior Loken Syndrome
Overview
A rare inherited disorder characterized by kidney dysfunction and progressive eye disease
Symptoms
* Thirst * Excessive urination * Mental retardation * Progressive vision loss * Blindness * Arterial hypertension * Tubulointerstitial nephropathy * Anemia * Increased blood urea nitrogen * Increased blood creatinine level * Thickening of kidney filtration tissues * Endstage kidney disease * Polyuria * Enuresis * Inability to concentrate urine * Kidney failure * Metabolic acidosis * Growth retardation * Renal salt wasting * Tapetoretinal degeneration * Retinitis pigmentosa
Prognosis
Prognosis of Senior-Loken Syndrome: poor with death occurring before adulthood