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  FASEB Helicase and Nucleic Acid-based Machine Conference

  21 - 26 July, 2019

  Conference Summary This FASEB Science Research Conference (SRC), which was first held in 2001, is the only one of its kind. It focuses on the structures and functions of helicases and helicase-like motors as components of fundamentally important supramolecular machines, and it explores their regulation and key roles in human diseases. This meeting brings together a diverse group of academic and industry researchers who are focused on the functions and roles of helicases and helicase-like motors. The meeting includes a strong contingent of structural and mechanistic biochemists who aim to elucidate molecular mechanisms of helicases. Diverse groups of researchers who study cellular processes and critical human diseases in which helicase proteins perform critical roles also attend. The central themes of the meeting are: 1) Extend our understanding of the molecular structures, mechanisms, and functions of helicase proteins; 2) Explore how helicases and helicase-like motors are integrated into complex machines and pathways to perform key roles in fundamental cellular processes; 3) Develop our understanding of how deficiencies in the functions of helicase proteins cause or contribute to important human diseases. Conference sessions will feature exciting new findings and discussions in key areas including: Helicase structure and mechanism Helicases associated with genomic instability, cancer, and aging The diverse mechanisms and roles of RNA helicases in biological processes Helicases involved in granule formation and subcellular RNA localization Nonconventional roles of helicases in nucleic acid metabolism ATP-dependent remodeling of ribonucleoprotein complexes by helicases Helicases engaged in chromatin remodeling and gene expression Helicases in DNA replication, repair, and recombination: links to genome homeostasis The opening keynote lecture will be presented by Chris Lima, PhD (Memorial Sloan Kettering Cancer Center). The meeting will also feature three poster sessions and career development workshops aimed toward young investigators and women in science.

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