Pelger-Huet anomaly
Overview
A rare blood disorder characterized by abnormal neutrophils which is a type of white blood cell. The condition can be inherited or result from bone marrow disorders.
Symptoms
* Abnormal neutrophils
Causes
-birth trauma (inadequate oxygen supply to the brain, blood incompatibility, or hemorrhage) -perinatal infection -anoxia (after respiratory or cardiac arrest) -infectious diseases (meningitis, encephalitis, or brain abscess) -ingestion of toxins (mercury, lead, or carbon monoxide) -tumors of the brain -inherited disorders or degenerative disease, such as phenylketonuria or tuberous sclerosis -head injury or trauma -metabolic disorders, such as hypoglycemia or hypoparathyroidism -stroke (hemorrhage, thrombosis, or embolism). Alcohol withdrawal can cause nonep-ileptic seizures.
Prognosis
The 'prognosis' of Pelger-Huet anomaly usually refers to the likely outcome of Pelger-Huet anomaly. The prognosis of Pelger-Huet anomaly may include the duration of Pelger-Huet anomaly, chances of complications of Pelger-Huet anomaly, probable outcomes, prospects for recovery, recovery period for Pelger-Huet anomaly, survival rates, death rates, and other outcome possibilities in the overall prognosis of Pelger-Huet anomaly. Naturally, such forecast issues are by their nature unpredictable.
Treatment
Generally, treatment of epilepsy consists of anticonvulsant therapy to reduce the number of future seizures. The most commonly prescribed drugs include phenytoin, carbamazepine, phenobarbital, gabapentin, or primidone administered individually for generalized tonic-clonic seizures and complex partial seizures. Valproic acid, clonazepam, and ethosuximide are commonly prescribed for absence seizures. Gabapentin and felbamate are also anticonvulsant drugs. A patient taking anticonvulsant medications requires monitoring for toxic signs: nystagmus, ataxia, lethargy, dizziness, drowsiness, slurred speech, irritability, nausea, and vomiting. If drug therapy fails, treatment may include surgical removal of a demonstrated focal lesion to attempt to stop seizures. Emergency treatment of status epilepticus usually consists of diazepam (or lorazepam), phenytoin, or phenobarbital; dextrose 50% I.V. (when seizures are secondary to hypoglycemia); and thiamine I.V. (in chronic alcoholism or withdrawal).