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Achillion Granted Twentieth Patent for Factor D Portfolio

3.5 from 2 votes
Wednesday, May 15, 2019

BLUE BELL, Pa., USA-- Achillion Pharmaceuticals, Inc. (Nasdaq: ACHN) ), a clinical-stage biopharmaceutical company dedicated to transforming the lives of patients and families affected by complement-mediated diseases, announced that the U.S. Patent and Trademark Office (USPTO) issued U.S. Patent #10,287,301 to Achillion for ACH-5548, its next-generation orally administered complement factor D small molecule inhibitor product candidate. This patent covers the composition of matter of ACH-5548, and a pharmaceutical composition that includes ACH-5548, a key mediator in the complement alternative pathway (AP). This issued patent will be the twentieth patent that the USPTO has granted to Achillion for its complement factor D portfolio of small molecules. Achillion currently has over one hundred global patent applications and patents including the composition of matter and method of use for its complement-related research program.

"Our intellectual property estate continues to yield issued patents stemming from our pioneering efforts in the discovery and development of oral small molecule factor D inhibitors, both in the United States and foreign countries. Achillion now has issued U.S. patents claiming the composition of matter for all three of its clinical development compounds, ACH-4471, ACH-5228 and ACH-5548," commented Joseph Truitt, President and Chief Executive Officer of Achillion. "We believe this extensive patent portfolio provides a foundation to support the broader application of our factor D inhibitors in hematology and nephrology and potentially other therapeutic areas including ophthalmology and neurology."

About the Achillion Complement Factor D Portfolio

Achillion has leveraged its internal discovery capabilities and a novel complement-related platform to develop oral small molecule drug candidates that are inhibitors of complement factor D. Factor D is an essential serine protease involved in the AP of the complement system, a part of the innate immune system. Achillion's complement platform is focused on seeking to advance oral small molecules that inhibit the AP and can potentially be used in the treatment of immune-related diseases in which complement AP plays a critical role. Potential indications currently being evaluated for these compounds include paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy (C3G), and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).

About Achillion Pharmaceuticals

Achillion Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on advancing its oral small molecule complement inhibitors into late-stage development and commercialization. Research has shown that an overactive complement system plays a critical role in multiple disease conditions including the therapeutic areas of nephrology, hematology, ophthalmology and neurology. Achillion is initially focusing its drug development activities on complement-mediated diseases where there are no approved therapies or where existing therapies are inadequate for patients. Potential indications being evaluated for its compounds include paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy (C3G), and immune complex membranoproliferative glomerulonephritis (IC-MPGN). Each of the product candidates in the Company's oral small molecule portfolio was discovered in its laboratories and is wholly owned. To advance its investigational product candidates into Phase 3 clinical trials and commercialization, the Company plans to work closely with key stakeholders including healthcare professionals, patients, regulators and payors. More information is available at Achillion's website

Brian Di Donato
Senior VP, Chief Financial Officer
Tel. (215) 709-3032

Susanne Heinzinger
Senior VP, Corporate Communications
Tel. (215) 709-3055

Source: Achillion Pharmaceutical
3.5 from 2 votes
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by Abidemi Uruejoma
by Abidemi Uruejoma
by Abidemi Uruejoma