Close
Close

Chondromalacia

Beclin1 modulates bone homeostasis by regulating osteoclast and chondrocyte differentiation.
Icon for Wiley Related Articles

Beclin1 modulates bone homeostasis by regulating osteoclast and chondrocyte differentiation.

J Bone Miner Res. 2019 May 10;:

Authors: Arai A, Kim S, Goldshteyn V, Kim T, Park NH, Wang CY, Kim R

Abstract
Autophagy, an important cellular recycling process whereby macromolecules or organelles are encapsulated by autophagosome and degraded upon merging with lysosome, is recently shown to play an essential role in bone biology. However, the involvement of autophagy in bone and bone-related cells remains unclear. Here, we show that Beclin1, an autophagy-related (ATG) protein involved in autophagy initiation, plays a pivotal role in osteoclasts. Autophagy was activated during osteoclast differentiation in vitro. Beclin1 was enhanced and required for osteoclast differentiation. Mechanistically, we found that TRAF6-mediated ubiquitination of Beclin1 at K117, but not ULK1-mediated phosphorylation, is required for RANKL-stimulated osteoclast differentiation. In vivo, mice lacking Becn1 in CstK-expressing cells exhibited in increased cortical bone thickness due to impaired osteoclasts' function. Interestingly, these mice also exhibited diminished trabecular bone mass, which was associated with defect in cartilage formation and chondrocyte differentiation. Collectively, our study highlights the functional importance of autophagy in osteoclasts and chondrocytes, and identifies autophagy as a potential therapeutic target for managing bone-related diseases. This article is protected by copyright. All rights reserved.

PMID: 31074883 [PubMed - as supplied by publisher]

Videos
by Abidemi Uruejoma
43 views
by Abidemi Uruejoma
61 views
by Abidemi Uruejoma
65 views
Latest Research