Hereditary angioedema

Angioedema: Perioperative management.
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Angioedema: Perioperative management.

SAGE Open Med Case Rep. 2017;5:2050313X17713912

Authors: Maynard AA, Burger CF, Schlesinger JJ

OBJECTIVE: To describe the perioperative management of a patient with acquired angioedema (AAE).
METHODS: A 66-year-old Caucasian male presented from an outside hospital with a history of acquired angioedema and gastrointestinal stromal tumor-related intractable urticaria and mastocytosis. He was admitted for urgent laparoscopic partial gastrectomy, secondary to gastric outlet obstruction symptomatology. Previous combined attacks were characterized by a widespread rash, abdominal pain and respiratory distress resulting in hospitalization. Following preoperative consultation with the patient's allergist and a hospital pharmacist, he was treated preoperatively with fresh frozen plasma and his home prednisone dose. C1-inhibitor (Berinert®) was on standby along with epinephrine, given that the underlying etiology (C1- inhibitor deficiency vs histaminergic) was not known.
RESULTS: There were no intraoperative complications, and the patient was discharged home 3 days after the procedure.
CONCLUSIONS: Optimization of perioperative outcomes in patients, especially during urgent or emergent surgery, with a history of angioedema requires the development of a patient-specific perioperative plan, including prophylaxis, rescue therapies and opioid-sparing strategies.

PMID: 28634542 [PubMed - in process]

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