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Mantle cell lymphoma

WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas.
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WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas.

Br J Pharmacol. 2017 Jul 12;:

Authors: Janovská P, Bryja V

Abstract
In this review, we discuss the intricate roles of the WNT signaling network in the development and progression of mature B cell-derived hematological malignancies, with a focus on chronic lymphocytic leukemia (CLL) and related B cell lymphomas. We review the current literature and highlight the differences between the β-catenin-dependent and independent branches of WNT signaling. Special attention is paid to the role of the non-canonical WNT/Planar cell polarity (PCP) pathway, mediated by the WNT5-ROR1-Dishevelled (DVL) signaling axis in CLL. This is mainly because WNT/PCP co-receptor ROR1 was found overexpressed in CLL and WNT/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutic targeting the WNT signaling pathways as an approach to disrupt the crucial interaction between malignant cells and their microenvironment. We urge the need of research in this direction also in other lymphomas, namely diffuse large B cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma, and follicular lymphoma where WNT signaling pathway likely plays a similar role.

PMID: 28703283 [PubMed - as supplied by publisher]

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