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Fumarate Hydratase Expression is Retained in Atypical Intradermal Smooth Muscle Neoplasms and Cutaneous Leiomyosarcomas.
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Fumarate Hydratase Expression is Retained in Atypical Intradermal Smooth Muscle Neoplasms and Cutaneous Leiomyosarcomas.

Histopathology. 2017 Jul 13;:

Authors: Coy S, Doyle LA

Abstract
Fumarate hydratase (fumarase) is a ubiquitous enzyme that catalyzes the conversion of fumarate to S-malate in the tricarboxylic acid cycle and amino acid metabolism. A subset of leiomyomas and renal cell carcinomas (RCC) demonstrate loss of function of fumarase, which may occur through mutation or deletion of the FH gene on chromosome 1q42.3-q43 in a sporadic or germline fashion. Heterozygous germline loss of function results in hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC). HLRCC is characterized by development of multiple pilar and uterine leiomyomas, and early development of aggressive RCCs. This article is protected by copyright. All rights reserved.

PMID: 28703412 [PubMed - as supplied by publisher]

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