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Cholestasis

Why Doesn't Primary Biliary Cholangitis Respond to Immunosuppressive Medications?

Why Doesn't Primary Biliary Cholangitis Respond to Immunosuppressive Medications?

Curr Hepatol Rep. 2017;16(2):119-123

Authors: Molinaro A, Marschall HU

Abstract
PURPOSE OF REVIEW: The purpose of this review is to discuss reasons why immunosuppressive therapy so far failed in Primary Biliry Cholangitis.
RECENT FINDINGS: Even targeted immunosuppressive therapy seems ineffective or potentially harmful.
SUMMARY: Bile acid-mediated cholangiocyte damage, facilitated by insufficient bicarbonate secretion, seems to attenuate the anti-inflammatory and anti-fibrotic actions of immunosuppressant and immunomodulatory drugs in a clinically significant way.

PMID: 28706773 [PubMed]

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