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Pulmonary Arterial Hypertension

Pulmonary artery hypertension: pertinent vasomotorial cytokines.
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Pulmonary artery hypertension: pertinent vasomotorial cytokines.

Eur Cytokine Netw. 2017 Mar 01;28(1):1-7

Authors: Yuan SM

Abstract
Pulmonary artery hypertension is a syndrome that shows similar clinical and pathophysiological features characterized by elevated pulmonary arterial pressure and resistance. There have been a series of hypotheses trying to describe the development of pulmonary artery hypertension; however, none of them perfectly explains its pathogenesis. To highlight the pathogenesis, novel vasomotorial cytokines including hypoxia-inducible factor-1α, endothelin-1, urotensin II, Krüppel-like factor 4, calcitonin gene-related peptide, angiopoietins, and serotonin closely related to pulmonary artery hypertension are discussed. The development of the new agents relating to these cytokines may improve the relevant treatment strategies.

PMID: 28840840 [PubMed - in process]

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