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Hereditary angioedema

The relationship between anxiety and quality of life in children with hereditary angioedema.
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The relationship between anxiety and quality of life in children with hereditary angioedema.

Pediatr Allergy Immunol. 2017 Jul 10;:

Authors: Kessel A, Farkas H, Kivity S, Veszeli N, Kőhalmi KV, Engel-Yeger B

Abstract
BACKGROUND: The severe life-threatening characteristics of hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) can affect anxiety levels among pediatric patients. This emotional burden together with the physical restrictions of C1-INH-HAE may decrease children's health-related quality of life (HRQoL).
OBJECTIVE: (1) To compare anxiety state and trait between children with C1-INH-HAE and healthy controls (2) To examine the relationship between the level of anxiety of children with C1-INH-HAE, their disease activity/affected sites and their HRQoL (3) To predict the HRQoL of children with C1-INH-HAE based on their anxiety level and disease activity/affected sites.
METHODS: Thirty-three children with C1-INH-HAE (aged 5-18 years) and 52 healthy controls were recruited from Israel and Hungary. All children completed the State Trait Anxiety Inventory for Children (STAIC), the Pediatric Quality of Life Inventory (Peds-QL) demographic questionnaire and a disease activity and site questionnaire. Disease activity was defined as the number of attacks in last year.
RESULTS: Both anxiety state and trait were significantly higher among children with C1-INH-HAE as compared to the controls (44.74±10.56 vs. 38.76±10.67, p<0.01, 29.21±5.16 vs. 25.23±4.09, p<0.001 in comparison). Significant differences were found between C1-INH-HAE patients with HAE attacks, asymptomatic C1-INH-HAE patients and healthy controls in both anxiety state (F56,2=4.69, p=.001) and trait (F56,2=9.06, p<.0001). A higher anxiety trait was correlated with the number of angioedema affected sites (r=.52, p=.003). The presence of HAE attacks and higher anxiety trait predicted a lower HRQoL in children with C1-INH-HAE.
CONCLUSIONS: C1-INH-HAE children have higher anxiety trait and state which correlate with reduced HRQoL domains. This article is protected by copyright. All rights reserved.

PMID: 28692169 [PubMed - as supplied by publisher]

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