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ROS1 Rearrangement in a Case of Classic Biphasic Pulmonary Blastoma.
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ROS1 Rearrangement in a Case of Classic Biphasic Pulmonary Blastoma.

Int J Surg Pathol. 2017 Dec 01;:1066896917749928

Authors: Jenkins TM, Morrissette JJD, Kucharczuk JC, Deshpande CG

Abstract
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non-small cell lung carcinoma (NSCLC) presenting in adults in the fourth to fifth decade. The prognosis is poor and after surgical resection, therapeutic options are often limited. ROS1 is a proto-oncogene receptor tyrosine kinase that has been identified in some types of NSCLC. We report a case of a 36-year-old woman with CBPB, which was subsequently found to have a ROS1 rearrangement. This is the first reported case of a ROS1-rearranged CBPB. This finding has therapeutic implications as these tumors have the potential to be treated with receptor tyrosine kinase inhibitors.

PMID: 29295663 [PubMed - as supplied by publisher]

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