Close
Close

Waldenstrom macroglobulinemia

Atrial fibrillation as a complication of ibrutinib therapy: clinical features and challenges of management.
Related Articles

Atrial fibrillation as a complication of ibrutinib therapy: clinical features and challenges of management.

Leuk Lymphoma. 2017 Jun 20;:1-10

Authors: Thorp BC, Badoux X

Abstract
Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor finding increasingly widespread use in non-Hodgkin lymphoma. Evidence of an increased risk of atrial fibrillation (AF) emerged in Phase III studies with a median incidence of approximately 6%. The mechanism remains unknown, but inhibition of a cardioprotective pathway has been proposed. Ibrutinib induces a platelet function defect, increasing the bleeding risk of anticoagulation for AF stroke prophylaxis. Multiple potential drug interactions are an added complication. In this review we examine the characteristics and management of the reported cases of AF with ibrutinib and where possible make recommendations. The evidence suggests dose reduction or temporary suspension of drug, are feasible alternative to discontinuation. The optimum choice of thromboprophylaxis has not been determined, but we propose the use of novel anticoagulants (NOACs) and avoidance of anti-platelet agents where possible. Further research and consensus guidelines are required.

PMID: 28629235 [PubMed - as supplied by publisher]

Videos
by Abidemi Uruejoma
11 views
by Abidemi Uruejoma
16 views
by Abidemi Uruejoma
47 views
by Abidemi Uruejoma
47 views
Latest Research