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Primary vs Secondary Focal Segmental Glomerulosclerosis
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Overview

Focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in children and adolescents, as well as a leading cause of kidney failure in adults. It is also known as "focal glomerular sclerosis" or "focal nodular glomerulosclerosis." It accounts for about a sixth of the cases of nephrotic syndrome. (Minimal change disease (MCD) is by far the most common cause of nephrotic syndrome in children: MCD and primary FSGS may have a similar cause.)

Dr. Musab Hommos, a 3rd Year Fellow in Nephrology and Dr. Fernando Fervenza, a Nephrologist, both at Mayo Clinic in Rochester, MN, review results of their study appearing in the December 2017 issue of Mayo Clinic Proceedings, which was the first to comprehensively categorize the significance between primary and secondary incidents of focal segmental glomerulosclerosis, aiding clinicians in discriminating which patients would best benefit from immunosuppressive treatment.

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